CURRICULUM VITAE SFEIR

CURRICULUM VITAE SFEIR

Areas of Research Interest and Expertise: The linearity of chromosomes creates two major problems for eukaryotic cells: To surmount both problems, cells use telomeres, the specific nucleoprotein complexes that are essential to ensure genomic stability and promote cellular survival. The linearity of chromosomes creates two major problems for eukaryotic cells: The latter refers to the propensity of linear chromosome ends to be recognized as DNA double stranded breaks. Normal human somatic cells lack the activity of telomerase and gradually loose telomeric repeats during progressive division cycles until they ultimately undergo cellular senescence.

Mammalian polymerase theta promotes alternative-NHEJ and suppresses recombination. A second area of their interest is to understand how telomere dynamics impact stem cell function and leads to tumorigenesis, using the mouse as a model organism. PhD from Southwestern University. Stop pulling my strings – what telomeres taught us about the DNA damage response. Associate Professor, Department of Cell Biology.

Non-telomeric role for Rap1 in regulating metabolism and protecting against obesity.

Rana Salam Curriculum Vitae

Journal of Cell Science. Normal human somatic cells lack the activity of telomerase and gradually loose telomeric repeats during progressive division cycles until they ultimately undergo cellular senescence. Is this your profile?

The latter refers to the propensity of linear chromosome ends to be recognized as DNA double stranded breaks. PhD from Southwestern University.

  DRUCKKOSTENZUSCHUSS DISSERTATION STIPENDIUM

A second area of interest to us is to understand how telomere dynamics impact stem cell function and leads to tumorigenesis, using the mouse as a model organism. The linearity of chromosomes creates two major problems for eukaryotic cells: Normal human somatic cells lack the activity of telomerase and gradually loose telomeric repeats during progressive division cycles until they ultimately undergo cellular senescence.

curriculum vitae sfeir

Areas of Research Interest and Expertise: The former stems from the inherent inability of the replication machinery to fully duplicate linear templates. A second area of their interest is to understand how telomere dynamics impact stem cell function and leads to tumorigenesis, using the mouse as a model organism.

The linearity of chromosomes creates two major problems for eukaryotic cells: Polymerase theta is a robust terminal transferase that oscillates between three different mechanisms during end-joining. Associate Professor, Department of Cell Biology.

Hesam Rahmanian Curriculum Vitae – Selections Arts

Telomeres are replenished by telomerase, a reverse transcriptase that is active in the germ line and during early embryonic development. Skip to Main Content. To surmount both problems, cells use telomeres, the specific nucleoprotein complexes that are essential to ensure genomic stability and promote cellular survival.

curriculum vitae sfeir

Mammalian polymerase theta promotes alternative-NHEJ and suppresses recombination. The former stems from the inherent inability of the replication machinery to curricilum duplicate linear templates.

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Opens in a new tab. Stop pulling my strings – what telomeres taught us about the DNA damage response.

Timo Nasseri Curriculum Vitae

Telomeres at a glance. See All Publications Telomeres are replenished by telomerase, a reverse transcriptase that is active in the germ line and during early embryonic development. The latter refers to the propensity of linear chromosome ends to be recognized as DNA double stranded breaks. Agnel Sfeir curriculjm mainly interested in understanding the basic mechanism that leads to telomere length resetting. In particular, we rely on nuclear reprograming as a platform to identify factors that regulate telomere length.

Our lab is mainly interested in understanding the basic mechanism that leads to telomere length resetting. Stressed telomeres without POT1 enhance tumorigenesis [Editorial]. To surmount both problems, cells use telomeres, the specific nucleoprotein complexes that are essential to ensure genomic stability and promote cellular survival.