BUCCAL FAST DISSOLVING FILM THESIS

BUCCAL FAST DISSOLVING FILM THESIS

The drug content was then determined by UV spectrophotometer at nm. The measured surface pH was found to be close to neutral in all the formulations which means that they have less potential to irritate the buccal mucosa and therefore they should be fairly comfortable. The images in Figure 2 show surface modifications based on the disintegrants used. Metformin hydrochloride Met , an antidiabetic drug, has poor bioavailability due to its high solubility and low permeability. The dissolution medium consisted of ml freshly deionized simulated saliva pH 6.

The release data were also kinetically analyzed 15 using the Korsmeyer—Peppas model. You can learn about our use of cookies by reading our Privacy Policy. Polymeric films as vehicle for buccal Delivery: The Physiodynamic properties of mucoadhesive polymeric films developed as female controlled drug delivery system. The authors express their gratitude to Dr. Barnhart S, Vondrak B.

Design and evaluation of propranolol hydrochloride buccal films.

[Full text] Development of polymer-bound fast-dissolving metformin buccal film wit | IJN

The percent moisture loss was calculated using following formula results are in table no. International Journal of Chem Tech Research. Lindgren S, Janzon L. The hydration ratio of the film was calculated using following formula.

In Vitro Dissolution Study drug release rate study: EudragitRL polymer with propylene glycol as plasticizer were readily prepared by solvent casting. The measured surface pH was found to buccap close to neutral in all fiilm formulations which means that they have less potential to irritate the buccal mucosa and therefore they should be fairly comfortable. Evaluation of free films. Drug delivery via the mucous membrane of the oral cavity.

  CURRICULUM VITAE DO WYPE NIENIA

In vitro stability evaluation of optimized formulation X1 with different environmental conditions, confirms the potential of films for longer storage.

Increase in weight of the film was determined at regular time intervals until a constant weight was obtained as shown in table no. The optimized amount of drug dissoling dissolved in 2ml of water and kept on sonication for proper dispersion. X1 was the best formulation showed Percent Elongation The prepared film was pulled by means of a pulley system.

Int J Chemtech Res. Fast-dissolving drug-delivery systems are considered advantageous over the existing conventional oral dosage forms like tablets, capsules, and syrups for being patient friendly.

The force was measured when the films broke results is shown in table no.

buccal fast dissolving film thesis

Kinetic analysis of in vitro release data In order to determine the release mechanism that provides the best description to the pattern of drug release, the in vitro release data were fitted to zeroorder, first-order, Hixson Crowell equation and Higuchi matrix model.

The solution was filtered using Whatman filter Paper. Design and characterization of mucoadhesive buccal patches containing cetylpyridinium chloride.

A solvent mixture of ethanol and water was required to keep both polymers in solution Evaluation of Prepared Films From the results of the tests for physical characterization conducted, it is observed that the weight and thickness of all film samples was uniform within each formulation.

Development of polymer-bound fast-dissolving metformin buccal film with disintegrants

The dissolution medium consisted of ml freshly deionized simulated saliva pH 6. The mechanical properties of the film gives idea about to what extent the disdolving can withstand the force or stress during processing, packaging, transport and handling. In view of these facts this drug can be considered as a suitable candidate for fast dissolving oral film.

  THESIS ANTITHESIS BETEKENIS

This study shows that it is possible to formulate fast dissolving films of dicyclomine HCL with the intention of obtaining better therapeutic efficiency with increasing bioavailability and improving patient compliance.

However, these formulations facilitated the immediate release of metformin and also maintained the therapeutic dosage of the drug administered through the buccal route. Mishra R, Amin A.

Eudragid RL were gast in texture, flexible and slightly translucent. Metformin was chosen as the model drug based on its physicochemical properties and pharmacological action.

buccal fast dissolving film thesis

Bhagvati ST, kuppasad IJ. The surface pH of the films was determined in order to investigate the possible side effects due to faat in pH in vivo, since an acidic or alkaline pH may cause irritation to the buccal mucosa. Drug Dev Ind Pharm. Aspartame used as a sweetener will successfully mask the bitter taste of the drug dicyclomine.

buccal fast dissolving film thesis

All other chemicals and reagents used were of analytical grade.